Extreme Forum
General Bodybuilding Discussion => Steroidi => Temu započeo: Kralj ist Back-Bakic April 23, 2008, 03:57:34 posle podne
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http://www.medicalnewstoday.com/articles/20441.php
http://66.102.9.104/translate_c?hl=de&ie=UTF-8&oe=UTF-8&langpair=en%7Cde&u=http://www.medicalnewstoday.com/articles/20441.php&prev=/language_tools
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pa ovi tekstovi govore o osobama koje boluju od distrofije misica...(pise Dystrophy Teraphy)?
Kralju, koji su nezeljeni efekti Miostatin Blokera? tj ako ga koristi zdrava osoba u svrhe bb-a?
i u kom je to obliku? tablete, ampule?
video sam u nekom katalogu suplemenata cak da se spominje neki suplement na bazi Miostatin Blokera?!
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Da bas tako, za Ljudi koje boluju od razgradnje misica!! Vec se koristi(tj.zloupotrebava u BB u USA!!) U Evropi jos nije dostupno i jako je skup taj Ljek!! To sto ima po prodavnice za proteine kataloge itd.. nema veze sa ovim!! Ovo je suvi beli prasak ko HCG i rastvara se sa sterilnom vodom ili slicno.. Udara se I.M u misic. Nezeljeni efekti jos i nisu bas istrazeni i dokazani!! Tvrde da samo misic raste i deluje lokalno!! ne ide na srce i druge organe!! Ali nezna se nikad??? sampo ime kaze Myiostatin bloker!! (citaj myostatin u google) Myiostatin je hormon u telu koji regulise rast misica!! Kad ga blokiras nema vise kontrole nad rast misica!! Raste misic ko kvasac!! To je vec Gen doping i manipulacija!! Ima slucajeva ovde u Nemacku koje bivse Sportiste iz DDR radzaju bebe sa taj deficit gen!! Ima cak i slike po netu od ta beba!!
Opasna stvar nepreporucuje se nikome!! Zdravog!!!
pa ovi tekstovi govore o osobama koje boluju od distrofije misica...(pise Dystrophy Teraphy)?
Kralju, koji su nezeljeni efekti Miostatin Blokera? tj ako ga koristi zdrava osoba u svrhe bb-a?
i u kom je to obliku? tablete, ampule?
video sam u nekom katalogu suplemenata cak da se spominje neki suplement na bazi Miostatin Blokera?!
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Da bas tako, za Ljudi koje boluju od razgradnje misica!! Vec se koristi(tj.zloupotrebava u BB u USA!!) U Evropi jos nije dostupno i jako je skup taj Ljek!! To sto ima po prodavnice za proteine kataloge itd.. nema veze sa ovim!! Ovo je suvi beli prasak ko HCG i rastvara se sa sterilnom vodom ili slicno.. Udara se I.M u misic. Nezeljeni efekti jos i nisu bas istrazeni i dokazani!! Tvrde da samo misic raste i deluje lokalno!! ne ide na srce i druge organe!! Ali nezna se nikad??? sampo ime kaze Myiostatin bloker!! (citaj myostatin u google) Myiostatin je hormon u telu koji regulise rast misica!! Kad ga blokiras nema vise kontrole nad rast misica!! Raste misic ko kvasac!! To je vec Gen doping i manipulacija!! Ima slucajeva ovde u Nemacku koje bivse Sportiste iz DDR radzaju bebe sa taj deficit gen!! Ima cak i slike po netu od ta beba!!
Opasna stvar nepreporucuje se nikome!! Zdravog!!!
pa ovi tekstovi govore o osobama koje boluju od distrofije misica...(pise Dystrophy Teraphy)?
Kralju, koji su nezeljeni efekti Miostatin Blokera? tj ako ga koristi zdrava osoba u svrhe bb-a?
i u kom je to obliku? tablete, ampule?
video sam u nekom katalogu suplemenata cak da se spominje neki suplement na bazi Miostatin Blokera?!
:) ;D 8)
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:o
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Znaci katastrofa meni se zgadile ove slike djake odakle ti ovo? :o
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:o
ovo je prejeb....
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Kažu da je u Nemačkoj, u Berlinu, 2000 god.rodjeno dete sa poremećajem u miostatin proteinu (genu), što uzrokuje nenormalan rast mišića...Ovo je slika tog super deteta sa 7 meseci starosti...
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Da bas ta je slika!! Bravo za prilog!!!
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Kralju,
znaci jednom kada blokiras gen miostatin, on nikada vise ne funkcionise? znaci unistava se u sustini gen, kod?
inace te price da deluje lokalno to mi nesto ne pije vodu... ipak MB ulazi u krvotok gde god ga ti ubrizgao zar ne? a tu napada srce sigurno ...
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Terapija ili Kura sa Myiostatin Bloker je kratka 4-6 nedelja!! U to vreme se uz te inekcije blokira izlucavanje Myiostatina i uz to povecavanje misicne mase(misicnog tkiva)!! Posle prestanka se opet sve regulise na normalu(u sustini)?? Ali nikad se nezna!! Nauka jos krije te studije o Myostatinu!! Steknute misice odrzavaju se dalje sa (obicnim) kurama AAS HGH Insulun itd...
Moze da se desi da se poremeti Gen te licnosti koja zloupotrebava taj bloker.. i prenese na potomak!! Zato prvo deca pa posle Myo... hahahah
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http://duggmirror.com/offbeat_news/A_Collection_of_Myostatin_Deficiency_Pictures/
Prosto neverovatno mi ovo deluje.....
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ovo je definitivno najjaca tvar za bodybuildere,pomjesana sa steroidima treningom i hranom netreba nam hcg niti insulin,koliko kosta otprilike kura sa time,dali mozda pedja zna.
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Brate ja ovo nikad nebih uzeo ni za dzabe,posle da budem necije zamorce neka hvala 8)
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Brate ja ovo nikad nebih uzeo ni za dzabe,posle da budem necije zamorce neka hvala 8)
pa ne mozes se od toga pretvorit u misha jbt
to na slici su pravi mishevi a ne bivshi ljudi
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Ma znam sumporni nego ko zna kakve posledice ostaju posle koriscenja ovog
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marvel comics
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Ha ha ha ma kako!
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marvel comics
haha
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marvel comics
marvel comics
Ti si CAR
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A Phase I/II trial of MYO-029 in Adult
Subjects with Muscular Dystrophy
Kathryn R. Wagner, MD, PhD,1 James L. Fleckenstein, MD,2 Anthony A. Amato, MD,3
Richard J. Barohn, MD,4 Katharine Bushby, MD,5 Diana M. Escolar, MD,6 Kevin M. Flanigan, MD,7
Alan Pestronk, MD,8 Rabi Tawil, MD,9 Gil I. Wolfe, MD,10 Michelle Eagle, PhD, MSc, MCSP, SRP,5
Julaine M. Florence, PT, DPT,8 Wendy M. King, PT,11 Shree Pandya, MS, PT,9 Volker Straub, MD,5
Paul Juneau, MS,12 Kathleen Meyers, RN, BSN,13 Cristina Csimma, PharmD, MHP,14
Tracey Araujo, MSPharm,14 Robert Allen, MD,13 Stephanie A. Parsons, PhD,13 John M. Wozney, PhD,14
Edward R. LaVallie, PhD,14 and Jerry R. Mendell, MD11
Objective: Myostatin is an endogenous negative regulator of muscle growth and a novel target for muscle diseases. We conducted
a safety trial of a neutralizing antibody to myostatin, MYO-029, in adult muscular dystrophies (Becker muscular dystrophy,
facioscapulohumeral dystrophy, and limb-girdle muscular dystrophy).
Methods: This double-blind, placebo-controlled, multinational, randomized study included 116 subjects divided into sequential
dose-escalation cohorts, each receiving MYO-029 or placebo (Cohort 1 at 1mg/kg; Cohort 2 at 3mg/kg; Cohort 3 at 10mg/kg;
Cohort 4 at 30mg/kg). Safety and adverse events were assessed by reported signs and symptoms, as well as by physical examinations,
laboratory results, echocardiograms, electrocardiograms, and in subjects with facioscapulohumeral dystrophy, funduscopic
and audiometry examinations. Biological activity of MYO-029 was assessed through manual muscle testing, quantitative
muscle testing, timed function tests, subject-reported outcomes, magnetic resonance imaging studies, dual-energy radiographic
absorptiometry studies, and muscle biopsy.
Results: MYO-029 had good safety and tolerability with the exception of cutaneous hypersensitivity at the 10 and 30mg/kg
doses. There were no improvements noted in exploratory end points of muscle strength or function, but the study was not
powered to look for efficacy. Importantly, bioactivity of MYO-029 was supported by a trend in a limited number of subjects
toward increased muscle size using dual-energy radiographic absorptiometry and muscle histology.
Interpretation: This trial supports the hypothesis that systemic administration of myostatin inhibitors provides an adequate
safety margin for clinical studies. Further evaluation of more potent myostatin inhibitors for stimulating muscle growth in
muscular dystrophy should be considered.
Ann Neurol 2008;63:561–571
Muscular dystrophies are a diverse set of distinct, inherited
disorders that commonly manifest with progressive
skeletal muscle weakness and wasting. Despite
substantial progress in understanding the pathophysiological
basis of these diseases, no pharmacological therapies
have been identified that increase muscle
strength, other than corticosteroids, which provide a
modest benefit to some patients with these disorders.1
For muscular dystrophies that present in adulthood,
there have been only a few small clinical trials, and
none involved a novel therapeutic agent.2–6 This article
describes a clinical trial of a novel agent, an inhibitor
of myostatin, designed to increase muscle mass and
strength in several of the most common forms of adult
muscular dystrophy.
Myostatin, a member of the transforming growth
From the 1Departments of Neurology and Neuroscience, The Johns
Hopkins University School of Medicine, Baltimore, MD; 2Department
of Internal Medicine, University of Oklahoma College of
Medicine at Tulsa, Tulsa, OK; 3Department of Neurology, Brigham
and Women’s Hospital, Boston, MA; 4Department of Neurology,
University of Kansas Medical Center, Kansas City, KS; 5University
of Newcastle Upon Tyne, Institute of Human Genetics, Newcastle
Upon Tyne, United Kingdom; 6Children’s National Medical Center,
Research Center Genetic Medicine, Washington, DC; 7University
of Utah School of Medicine, Departments of Neurology, Human
Genetics, and Pathology, Salt Lake City, UT; 8Neuromuscular
Division, Washington University School of Medicine, St. Louis,
MO; 9Neuromuscular Disease Center, University of Rochester
Medical Center, Rochester, NY; 10University of Texas Southwestern
Medical Center, Dallas, TX; 11Department of Pediatrics and Neurology,
Columbus Children’s Research Institute, Ohio State University,
Columbus, OH; 12Senior Statistician, MMS Holdings, Inc.,
Canton, MI; 13Wyeth Research, Collegeville, PA; and 14Wyeth Research,
Cambridge, MA.
Received Oct 31, 2007, and in revised form Dec 18. Accepted for
publication Dec 21, 2007.
Current address for Dr Csimma: Clarus Ventures, Cambridge, MA.
Published online Mar 11, 2008, in Wiley InterScience
(www.interscience.wiley.com). DOI: 10.1002/ana.21338
Address correspondence to Dr Wagner, The Johns Hopkins University
School of Medicine, Department of Neurology, Meyer
5-119, 600 North Wolfe Street, Baltimore, MD 21287-7519.
E-mail: kwagner@jhmi.edu
ORIGINAL ARTICLES
© 2008 American Neurological Association 561
Published by Wiley-Liss, Inc., through Wiley Subscription Services
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http://www.biotechnologie.de/bio/generator/Navigation/English/root.html
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http://www.musculardevelopment.com/content/view/1192/51/
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http://www.musculardevelopment.com/content/view/1542/51/
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Muscle Mutants
Eric Henderson, Ph.D.
What would happens if your muscles grew all the time? Well, you would be a giant “myoball” and live about 8 minutes. Cell death (apoptosis) and inhibition of cell growth is part of normal development and once you have grown to your adult size, your body really does not want to keep growing.
That is why we have to stress our bodies to get additional muscle growth. That is also why we need to vary our exercises to continually confuse your muscles and force them to continually grow to compensate for their ever changing environment
Now the fun begins. Let’s think of all the things working against us in terms of muscle growth.
Age: as a 51 year old I can tell you that my muscles do not want to grow a nanometer without extremely convincing reasons to do so. Lower testosterone, cross-linked muscle and support tissue. The battle is intense!
2. Oxidative stress: Again, compensating for all those free radicals I generate when working out gets tougher and tougher with age. Try The Feast, it works.
Myostatin and Follistatin. What? These are two proteins involved in the suppression of muscle growth. If you walk all day and your muscles responded accordingly your gluts and quads would be the size of a house! Myostatin and Follistatin are proteins that inhibit muscle growth. If you shut these proteins down you get incredible increases in native (non-exercise induced) muscle growth. The mouse on the bottom has had his myostatin/follistatin activity genetically decreased - compare him to the normal mouse on the top.
Now, theory time. Have you ever known those lucky guys in the gym who start out with great 6 packs and then after 2 weeks of lifting have giant pecs and biceps? Yeah, those guys (and girls) are likely to be, in my opinion, myostatin/follistatin mutants! That’s right folks, here come the X-man - the mutants are taking over. There is new evidence this is the case. In a study of racing dogs the best athletes were myostatin mutants!Wait! Before you freak out, remember that we are ALL mutants of one sort of another.
Now, for guys like me who are extremely hard gainers but follow all the “rules” (lots of health meals, intense workouts, rest, etc.) one likely explanation is that I am another form of myostatin/follistatin mutant. In my case, unfortunately, the myostatin/follistatin levels are likely to be abnormally high! That means, that as soon as I even think about lifting a weight, my body starts to shut down muscle growth.
Bummer!
So what do we do? Well, everything you can - short intense workouts, take lots of antioxidants (this enhances growth of muscle) and so on. But will we ever obtain the success of the genetically gifted? Not likely. Not with out gene therapy or buckets of cancer-inducing steroids. Still, even the skinniest myostatin mutant can make some progress. And it will not be long before someone comes up with a myostatin inhibitor that actually works (there are some on the market but they do not even come close to the Henderson A-list because they are essentially fractionated seaweed - stuff I could make in my lab in a day, but why, it does not work).
Why will this take so long? Consider this, anything that goes into your mouth goes through an acid wash that is designed and optimized over millions of years to break things down. So how the heck is a myostatin inhibitor going to get through your gut intact and with retention of biological activity - not likely!
It can happen (tylenol and a lot of other drugs work this way,for example) but it will be a long and tedious path to creating the ultimate myostatin inhibitor. And will it be legal, probably not.
So in the mean time, just work out hard, eat right and get rest. You will see improvements and you will find happiness! In the mean time I will try to figure out how to compensate for our many and varied genetic mutations - and let you know as soon as I come up with something!
Peace and Health,
Eric
(http://www.mudphudder.com/wp-content/uploads/2008/11/myostatin-mouse-limbs21.jpg)
(http://www.engr.iupui.edu/~turnerch/mighty%20mouse.gif)
(http://www.cealth.com/images/musclemouse.jpg)
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haha nabildovani pilici... lol
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Kakvi pilici, vidis da su neki misevi-pacovi! :-X